Immune checkpoint inhibitors in advanced or metastatic mucosal melanoma: a systematic review.

ABSTRACT:

Background

Conventional cytotoxic chemotherapy offers minor benefit to patients with mucosal melanoma (MM). Although immune checkpoint inhibitors (ICIs) have become the preferred approach in patients with advanced or metastatic cutaneous melanoma, the evidence of their clinical use for MM is still limited. This systematic review aims to summarize the efficacy and safety of ICIs in advanced or metastatic MM.

Methods

We searched electronic databases, conference abstracts, clinical trial registers and reference lists for relevant studies. The primary outcomes included the overall response rate (ORR), median progression-free survival (PFS), median overall survival (OS), one-year PFS rate, and one-year OS rate.

Results

This review identified 13 studies assessing anti-CTLA-

SUBMITTER: Li J 

PROVIDER: S-EPMC7238311 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature