Implications of NAD⁺ Metabolism in the Aging Retina and Retinal Degeneration.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) plays an important role in various key biological processes including energy metabolism, DNA repair, and gene expression. Accumulating clinical and experimental evidence highlights an age-dependent decline in NAD⁺ levels and its association with the development and progression of several age-related diseases. This supports the establishment of NAD⁺ as a critical regulator of aging and longevity and, relatedly, a promising therapeutic target to counter adverse events associated with the normal process of aging and/or the development and progression of age-related disease. Relative to the above, the metabolism of NAD⁺ has been the subject of numerous investigations in various cells, tissues, and organ system

SUBMITTER: Jadeja RN 

PROVIDER: S-EPMC7238357 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature