Prognostic and diagnostic value of circRNA expression in colorectal carcinoma: a meta-analysis.

ABSTRACT:

Background

Circular RNAs (circRNAs) are research hotspots in the network of noncoding RNAs in numerous tumours. The purpose of our study was to evaluate the clinicopathological, prognostic and diagnostic value of circRNAs in colorectal cancer.

Methods

The PubMed, Cochrane Library, and Web of Science online databases were searched for relevant studies before May 15, 2019. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between circRNAs expression, and overall survival (OS) and clinical parameters. Pooled sensitivity, specificity, and the area under the curve (AUC) were employed to assess the diagnostic value of circRNAs.

Results

A total of 19 studies were enrolled in this meta-analysis, with

SUBMITTER: Yuan J 

PROVIDER: S-EPMC7238613 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature