Smash++: an alignment-free and memory-efficient tool to find genomic rearrangements.

ABSTRACT:

Background

The development of high-throughput sequencing technologies and, as its result, the production of huge volumes of genomic data, has accelerated biological and medical research and discovery. Study on genomic rearrangements is crucial owing to their role in chromosomal evolution, genetic disorders, and cancer.

Results

We present Smash++, an alignment-free and memory-efficient tool to find and visualize small- and large-scale genomic rearrangements between 2 DNA sequences. This computational solution extracts information contents of the 2 sequences, exploiting a data compression technique to find rearrangements. We also present Smash++ visualizer, a tool that allows the visualization of the detected rearrangements along with their self- and relative complexity, by ge

SUBMITTER: Hosseini M 

PROVIDER: S-EPMC7238676 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature