MiR-195-5p Suppresses Lung Cancer Cell Proliferation, Migration, and Invasion Via FOXK1.

ABSTRACT: Lung cancer remains one of the leading causes of cancer deaths around the world. Previous studies have shown that microRNAs have pivotal functions in tumorigenesis including lung cancer. It is reported that microRNA-195-5p acts as a tumor suppressor role in human cancers. However, the function and molecular mechanism of microRNA-195-5p in lung cancer progression is still unclear. In the present study, the results showed that the expression of microRNA-195-5p was downregulated both in lung cancer tissues and in lung cancer cell lines. Enhanced expression of microRNA-195-5p inhibited cell proliferation, migration, and invasion in lung cancer cells. Furthermore, Forkhead box k1 was identified as the direct target of microRNA-195-5p. Forkhead box k1 overexpression could restore the repressed c

SUBMITTER: Long Z 

PROVIDER: S-EPMC7238777 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature