The distribution of immune cells within combined hepatocellular carcinoma and cholangiocarcinoma predicts clinical outcome.

ABSTRACT:

Background

This study aimed to investigate the clinical relevance of the immune microenvironment in patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-ICC).

Patients and methods

The density of tumor-infiltrating CD3⁺ , CD8⁺ , CD163⁺ , and Foxp3⁺ immune cells, as well as Programmed cell death 1, Programmed cell death-ligand 1, and Tumor necrosis factor receptor superfamily member 4, was measured in the peritumor liver, tumor invasive margin, and intratumor subregions of 56 cHCC-ICC by immunohistochemistry. The immune index was established to stratify patients. Prognostic significance of immune cell subsets and immune indices was evaluated.

Results

The distribution of immune cells was highly heterogen

SUBMITTER: Zheng BH 

PROVIDER: S-EPMC7239312 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature