Study protocol and pilot results of an observational cohort study evaluating effect of red blood cell transfusion on oxygenation and mitochondrial oxygen tension in critically ill patients with anaemia: the INsufficient Oxygenation in the Intensive Care Unit (INOX ICU-2) study.

ABSTRACT:

Introduction

The recently developed protoporphyrin IX-triple state lifetime technique measures mitochondrial oxygenation tension (mitoPO₂) in vivo at the bedside. MitoPO₂might be an early indicator of oxygen disbalance in cells of critically ill patients and therefore may support clinical decisions regarding red blood cell (RBC) transfusion. We aim to investigate the effect of RBC transfusion and the associated changes in haemoglobin concentration on mitoPO₂ and other physiological measures of tissue oxygenation and oxygen balance in critically ill patients with anaemia. We present the protocol and pilot results for this study.

Methods and analysis

We perform a prospective multicentre observational study in three mixed intensive care units in

SUBMITTER: Baysan M 

PROVIDER: S-EPMC7239524 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature