Administration of Tranexamic Acid Improves Long-Term Outcomes in Total Knee Arthroplasty.

ABSTRACT:

Background

Blood transfusion in total knee arthroplasty (TKA) is associated with increased morbidity, including periprosthetic joint infection (PJI). Tranexamic acid (TXA) reduces blood transfusion rates, but there is limited evidence demonstrating improved outcomes in TKA resulting from TXA administration. The objectives of this study are determining whether TXA is associated with decreased rate of PJI, decreased rate of outcomes associated with PJI, and whether there are differences in rates of adverse events.

Methods

A multicenter cohort study comprising 23,421 TKA compared 4423 patients receiving TXA to 18,998 patients not receiving TXA. Primary outcome was PJI within 2 years of TKA. Secondary outcomes included revision surgery, irrigation and debridement, transfusion, a

SUBMITTER: Drain NP 

PROVIDER: S-EPMC7239733 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature