Effects of 5-HT_2C, 5-HT_1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours.

ABSTRACT:

Rationale

Problematic patterns of gambling are characterised by loss of control and persistent gambling often to recover losses. However, little is known about the mechanisms that mediate initial choices to begin gambling and then continue to gamble in the face of losing outcomes.

Objectives

These experiments first assessed gambling and loss-chasing performance under different win/lose probabilities in C57Bl/6 mice, and then investigated the effects of antagonism of 5-HT_2CR with SB242084, 5-HT_1AR agonism with 8-OH-DPAT and modafinil, a putative cognitive enhancer.

Results

As seen in humans and other species, mice demonstrated the expected patterns of behaviour as the odds for winning were altered increasing gambling and loss-chasing when winning

SUBMITTER: Humby T 

PROVIDER: S-EPMC7239826 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature