Risk factors for severe bleeding events during warfarin treatment: the influence of sex, age, comorbidity and co-medication.

ABSTRACT:

Purpose

To investigate risk factors for severe bleeding during warfarin treatment, including the influence of sex, age, comorbidity and co-medication on bleeding risk.

Methods

Patients initiating warfarin treatment between 2007 and 2011 were identified in the nationwide Swedish Prescribed Drug Register, and diagnoses of severe bleeding were retrieved from the National Patient Register. Hazard ratios (HR) with 95% confidence intervals (CI) for severe bleeding were estimated using multiple Cox regression adjusting for indications and including covariates age, sex, comorbidities and co-medications. Interactions between sex and other covariates were investigated.

Results

The study cohort included 232,624 patients ≥ 18 years (101,011 women and 131,613 men). The incidence r

SUBMITTER: Rydberg DM 

PROVIDER: S-EPMC7239828 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature