Dopaminergic contributions to behavioral control under threat of punishment in rats.

ABSTRACT:

Rationale

Excessive intake of rewards, such as food and drugs, often has explicit negative consequences, including the development of obesity and addiction, respectively. Thus, choosing not to pursue reward is the result of a cost/benefit decision, proper execution of which requires inhibition of behavior. An extensive body of preclinical and clinical evidence implicates dopamine in certain forms of inhibition of behavior, but it is not fully known how it contributes to behavioral inhibition under threat of explicit punishment.

Objectives

To assess the involvement of midbrain dopamine neurons and their corticostriatal output regions, the ventral striatum and prefrontal cortex, in control over behavior under threat of explicit (foot shock) punishment in rats.

Methods

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SUBMITTER: Verharen JPH 

PROVIDER: S-EPMC7239833 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature