Automated detection of the head-twitch response using wavelet scalograms and a deep convolutional neural network.

ABSTRACT: Hallucinogens induce the head-twitch response (HTR), a rapid reciprocal head movement, in mice. Although head twitches are usually identified by direct observation, they can also be assessed using a head-mounted magnet and a magnetometer. Procedures have been developed to automate the analysis of magnetometer recordings by detecting events that match the frequency, duration, and amplitude of the HTR. However, there is considerable variability in the features of head twitches, and behaviors such as jumping have similar characteristics, reducing the reliability of these methods. We have developed an automated method that can detect head twitches unambiguously, without relying on features in the amplitude-time domain. To detect the behavior, events are transformed into a visual representation

SUBMITTER: Halberstadt AL 

PROVIDER: S-EPMC7239849 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature