ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes.

ABSTRACT: ETS1 has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear. We utilized the Cancer Genome Atlas (TCGA) database to analyze comprehensive functions of ETS1 in human breast cancer (BRCA) patients by investigating its expression patterns and methylation status in relation to clinical prognosis. ETS1 expression was significantly diminished by hyper-methylation of the ETS1 promoter region in specimens from BRCA patients compared to a healthy control group. Moreover, ETS1 ^high BRCA patients showed better prognosis and longer survival compared to ETS1 ^low BRCA patients. Consistent with clinical evidence, comparative transcr

SUBMITTER: Kim GC 

PROVIDER: S-EPMC7239993 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature