Resveratrol: Multi-Targets Mechanism on Neurodegenerative Diseases Based on Network Pharmacology.

ABSTRACT: Resveratrol is a natural polyphenol in lots of foods and traditional Chinese medicines, which has shown promising treatment for neurodegenerative diseases (NDs). However, the molecular mechanisms of its action have not been systematically studied yet. In order to elucidate the network pharmacological prospective effects of resveratrol on NDs, we assessed of pharmacokinetics (PK) properties of resveratrol, studied target prediction and network analysis, and discussed interacting pathways using a network pharmacology method. Main PK properties of resveratrol were acquired. A total of 13,612 genes related to NDs, and 138 overlapping genes were determined through matching the 175 potential targets of resveratrol with disease-associated genes. Gene Ontology (GO) function analysis and Kyoto Ency

SUBMITTER: Wang W 

PROVIDER: S-EPMC7240052 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature