Rapidly Switchable Universal CAR-T Cells for Treatment of CD123-Positive Leukemia.

ABSTRACT: Chimeric antigen receptor T cells (CAR-T) targeting CD19 or B cell maturation antigen (BCMA) are highly effective against B cell malignancies. However, application of CAR-T to less differentially expressed targets remains a challenge due to lack of tumor-specific antigens and CAR-T controllability. CD123, a highly promising leukemia target, is expressed not only by leukemic and leukemia-initiating cells, but also by myeloid, hematopoietic progenitor, and certain endothelial cells. Thus, CAR-T lacking fine-tuned control mechanisms pose a high toxicity risk. To extend the CAR-T target landscape and widen the therapeutic window, we adapted our rapidly switchable universal CAR-T platform (UniCAR) to target CD123. UniCAR-T efficiently eradicated CD123⁺ leukemia in vitro and

SUBMITTER: Loff S 

PROVIDER: S-EPMC7240059 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature