Vibrio cholerae OmpR Contributes to Virulence Repression and Fitness at Alkaline pH.

ABSTRACT: Vibrio cholerae is a Gram-negative human pathogen and the causative agent of the life-threatening disease cholera. V. cholerae is a natural inhabitant of marine environments and enters humans through the consumption of contaminated food or water. The ability to transition between aquatic ecosystems and the human host is paramount to the pathogenic success of V. cholerae The transition between these two disparate environments requires the expression of adaptive responses, and such responses are most often regulated by two-component regulatory systems such as the EnvZ/OmpR system, which responds to osmolarity and acidic pH in many Gram-negative bacteria. Previous work in our laboratory indicated that V. cholerae OmpR functioned as a virulence regulator through rep

SUBMITTER: Kunkle DE 

PROVIDER: S-EPMC7240085 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature