A New Equation for Calculation of Low-Density Lipoprotein Cholesterol in Patients With Normolipidemia and/or Hypertriglyceridemia.

ABSTRACT:

Importance

Low-density lipoprotein cholesterol (LDL-C), a key cardiovascular disease marker, is often estimated by the Friedewald or Martin equation, but calculating LDL-C is less accurate in patients with a low LDL-C level or hypertriglyceridemia (triglyceride [TG] levels ≥400 mg/dL).

Objective

To design a more accurate LDL-C equation for patients with a low LDL-C level and/or hypertriglyceridemia.

Design, setting, and participants

Data on LDL-C levels and other lipid measures from 8656 patients seen at the National Institutes of Health Clinical Center between January 1, 1976, and June 2, 1999, were analyzed by the β-quantification reference method (18 715 LDL-C test results) and were randomly divided into equally sized training and validation data sets. Using TG and

SUBMITTER: Sampson M 

PROVIDER: S-EPMC7240357 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature