GSK3787-Loaded Poly(Ester Amide) Particles for Intra-Articular Drug Delivery.

ABSTRACT: Osteoarthritis (OA) is a debilitating joint disorder affecting more than 240 million people. There is no disease modifying therapeutic, and drugs that are used to alleviate OA symptoms result in side effects. Recent research indicates that inhibition of peroxisome proliferator-activated receptor δ (PPARδ) in cartilage may attenuate the development or progression of OA. PPARδ antagonists such as GSK3787 exist, but would benefit from delivery to joints to avoid side effects. Described here is the loading of GSK3787 into poly(ester amide) (PEA) particles. The particles contained 8 wt.% drug and had mean diameters of about 600 nm. Differential scanning calorimetry indicated the drug was in crystalline domains in the particles. Atomic force microscopy was used to measure the Young's moduli of i

SUBMITTER: Villamagna IJ 

PROVIDER: S-EPMC7240550 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature