Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitro.

ABSTRACT: It has been widely shown that biomaterial surface topography can modulate host immune response, but a fundamental understanding of how different topographies contribute to pro-inflammatory or anti-inflammatory responses is still lacking. To investigate the impact of surface topography on immune response, we undertook a systematic approach by analyzing immune response to eight grades of medical grade polyurethane of increasing surface roughness in three in vitro models of the human immune system. Polyurethane specimens were produced with defined roughness values by injection molding according to the VDI 3400 industrial standard. Specimens ranged from 0.1 μm to 18 μm in average roughness (Ra), which was confirmed by confocal scanning microscopy. Immunological responses w

SUBMITTER: Segan S 

PROVIDER: S-EPMC7240656 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature