Promising Performance of 4HMS, a New Zirconium-89 Octadendate Chelator.

ABSTRACT: Over the last decade, the interest in zirconium-89 (⁸⁹Zr) as a positron-emitting radionuclide increased considerably because of its standardized production and its physical half-life (78.41 h), which matches the biological half-life of antibodies and its successful use in preclinical and clinical applications. So far, desferrioxamine (DFO), a commercially available chelator, has been mainly used as a bifunctional chelating system. However, there are some concerns regarding the in vivo stability of the [⁸⁹Zr]Zr-DFO complex. In this study, we report the synthesis of an acyclic N-hydroxy-N-methyl succinamide-based chelator (4HMS) with 8 coordination sites and our first investigations into the use of this new chelator for ⁸⁹Zr complexation.

SUBMITTER: Alnahwi AH 

PROVIDER: S-EPMC7240819 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature