HK3 is correlated with immune infiltrates and predicts response to immunotherapy in non-small cell lung cancer.

ABSTRACT:

Background

With the knowledge of tumor immunobiology deepening among researchers, the breakthroughs in the field of tumor immunotherapy in recent years have provided new approaches for cancer therapy. While patients who receive treatment are all at risk of side effects, about one-fifth of them have sustained responses. It is crucial to figure out the underlying mechanism of how the immune system regulates the nonsmall cell lung cancer (NSCLC) microenvironment to improve the benefit of immunotherapy. Regarding glucose metabolism, the initial step is to generate glucose-6-phosphate by phosphorylating glucose with hexokinases-3 (HK3). According to a recent study, HK3 has a functional role in the treatment of acute promyelocytic leukemia and colorectal cancer.

Results

Here, we s

SUBMITTER: Tuo Z 

PROVIDER: S-EPMC7240846 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature