Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure.

ABSTRACT:

Background

Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse transcriptase polymerase chain reaction (RT-PCR) are being used to rule out infection among high-risk persons, such as exposed inpatients and health care workers. It is critical to understand how the predictive value of the test varies with time from exposure and symptom onset to avoid being falsely reassured by negative test results.

Objective

To estimate the false-negative rate by day since infection.

Design

Literature review and pooled analysis.

Setting

7 previously published studies providing data on RT-PCR performance by time since symptom onset or SARS-CoV-2 exposure using samples from the upper respiratory tract (n = 1330).

Patients

A mix of i

SUBMITTER: Kucirka LM 

PROVIDER: S-EPMC7240870 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature