Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise.

ABSTRACT: Recently, administration of nicotinic acid (NA) at a pharmacological dose was found to induce a similar change in the muscle´s contractile and metabolic phenotype as observed in response to endurance exercise. Thus, the hypothesis was tested that combined NA administration and endurance exercise promotes the adaptation of muscle to regular exercise and improves the endurance performance to a greater extent than exercise alone. Thus, 30 adult mice were randomly divided into three groups of 10 mice/group. The control and the exercise (EX) group received an adequate NA diet, while the EX + NA group received a high NA diet. Mice of the EX and the EX + NA group were subjected to a treadmill endurance exercise program five times/week during the experimental period of 42 days. At day 41, enduranc

SUBMITTER: Ringseis R 

PROVIDER: S-EPMC7240961 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature