Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production.

ABSTRACT: After myocardial ischemia-reperfusion, fatty acid oxidation shows fast recovery while glucose oxidation rates remain depressed. A metabolic shift aimed at increasing glucose oxidation has shown to be beneficial in models of myocardial ischemia-reperfusion. However, strategies aimed at increasing glucose consumption in the clinic have provided mixed results and have not yet reached routine clinical practice. A better understanding of the mechanisms underlying the protection afforded by increased glucose oxidation may facilitate the transfer to the clinic. The purpose of this study was to evaluate if the modulation of reactive oxygen species (ROS) was involved in the protection afforded by increased glucose oxidation. Firstly, we characterized an H9C2 cellular model in which the use of gluco

SUBMITTER: Beltran C 

PROVIDER: S-EPMC7240969 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature