Endoglin (CD105) and VEGF as potential angiogenic and dissemination markers for colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is an important current problem concerning public health due to its high incidence and mortality. Advances in molecular and cellular knowledge and the detection of new disease biomarkers are very important to improve prognosis, prediction, and early diagnosis. In this study, we aimed to analyze the gene and protein expression levels of two angiogenic markers, VEGF and soluble Endoglin, during different tumor stages as well as at different stages of cancer treatment, to predict the diagnosis and evolution of colon and rectal cancer.

Material and methods

This study includes 133 CRC patients (93 with colon cancer and 40 with rectal cancer) on which the gene and protein expression of Endoglin (membrane and soluble form) and VEGF were analyzed b

SUBMITTER: Nogues A 

PROVIDER: S-EPMC7240983 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature