The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies.

ABSTRACT: The incidence of adenocarcinoma at the gastrooesophageal junction increased over the last years. Curative treatment for patients with upper gastrointestinal (UGI) malignancies, such as oesophageal and gastric tumours, is challenging and requires a multidisciplinary approach. Radical surgical resection with complete lymphadenectomy is the cornerstone of UGI cancer treatment. Combined with peri-operative treatment (i.e. by applying CROSS, EOX or FLOT regimen), the survival is even better than with surgery alone. However, peri-operative treatment is not effective in all patients, and the most effective strategy is a topic of active debate, as is reflected by varying treatment guidelines between countries. UGI cancers are (epi)genetically highly heterogeneous. It is thus not likely that a unif

SUBMITTER: Busslinger GA 

PROVIDER: S-EPMC7241074 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature