Microbiome-Metabolome Signature of Acute Kidney Injury.

ABSTRACT: Intestinal microbiota play a considerable role in the host's organism, broadly affecting its organs and tissues. The kidney can also be the target of the microbiome and its metabolites (especially short-chain fatty acids), which can influence renal tissue, both by direct action and through modulation of the immune response. This impact is crucial, especially during kidney injury, because the modulation of inflammation or reparative processes could affect the severity of the resulting damage or recovery of kidney function. In this study, we compared the composition of rat gut microbiota with its outcome, in experimental acute ischemic kidney injury and named the bacterial taxa that play putatively negative or positive roles in the progression of ischemic kidney injury. We investigated the l

SUBMITTER: Andrianova NV 

PROVIDER: S-EPMC7241241 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature