Drought Stress Responses in Context-Specific Genome-Scale Metabolic Models of Arabidopsis thaliana.

ABSTRACT: Drought perturbs metabolism in plants and limits their growth. Because drought stress on crops affects their yields, understanding the complex adaptation mechanisms evolved by plants against drought will facilitate the development of drought-tolerant crops for agricultural use. In this study, we examined the metabolic pathways of Arabidopsis thaliana which respond to drought stress by omics-based in silico analyses. We proposed an analysis pipeline to understand metabolism under specific conditions based on a genome-scale metabolic model (GEM). Context-specific GEMs under drought and well-watered control conditions were reconstructed using transcriptome data and examined using metabolome data. The metabolic fluxes throughout the metabolic network were estimated by flux balance analy

SUBMITTER: Siriwach R 

PROVIDER: S-EPMC7241242 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature