Impaired perfusion and capillary dysfunction in prodromal Alzheimer's disease.

ABSTRACT:

Introduction

Cardiovascular disease increases the risk of developing Alzheimer's disease (AD), and growing evidence suggests an involvement of cerebrovascular pathology in AD. Capillary dysfunction, a condition in which capillary flow disturbances rather than arterial blood supply limit brain oxygen extraction, could represent an overlooked vascular contributor to neurodegeneration. We examined whether cortical capillary transit-time heterogeneity (CTH), an index of capillary dysfunction, is elevated in amyloid-positive patients with mild cognitive impairment (prodromal AD [pAD]).

Methods

We performed structural and perfusion weighted MRI in 22 pAD patients and 21 healthy controls.

Results

We found hypoperfusion, reduced blood volume, and elevated CTH in the parietal

SUBMITTER: Nielsen RB 

PROVIDER: S-EPMC7241262 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature