Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation.

ABSTRACT: Scar formation is a natural result of almost all wound healing in adult mammals. Unfortunately, scarring disrupts normal tissue function and can cause significant physical and psychological distress. In addition to improving surgical techniques to limit scar formation, several therapies are under development towards the same goal. Many of these treatments aim to disrupt transforming growth factor β1 (TGFβ1) signaling, as this is a critical control point for fibroblast differentiation into myofibroblasts; a contractile cell that organizes synthesized collagen fibrils into scar tissue. The present study aimed to examine the role of hyperosmolar potassium gluconate (KGluc) on fibroblast function in skin repair. KGluc was first determined to negatively regulate fibroblast proliferation, metabo

SUBMITTER: Grasman JM 

PROVIDER: S-EPMC7241611 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature