A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice.

ABSTRACT: Salt is an essential nutrient; however, excessive salt intake is a prominent public health concern worldwide. Various physiological functions are associated with circadian rhythms, and disruption of circadian rhythms is a prominent risk factor for cardiovascular diseases, cancer, and immune disease. Certain nutrients are vital regulators of peripheral circadian clocks. However, the role of a high-fat and high-salt (HFS) diet in the regulation of circadian gene expression is unclear. This study aimed to investigate the effect of an HFS diet on rhythms of locomotor activity, caecum glucocorticoid secretion, and clock gene expression in mice. Mice administered an HFS diet displayed reduced locomotor activity under normal light/dark and constant dark conditions in comparison with those adminis

SUBMITTER: Yokoyama Y 

PROVIDER: S-EPMC7241774 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature