From trivalent to quadrivalent influenza vaccines: Public health and economic burden for different immunization strategies in Spain.

ABSTRACT:

Purpose

Quadrivalent influenza vaccine (QIV) includes the same strains as trivalent influenza vaccine (TIV) plus an additional B strain of the other B lineage. The aim of the study was to analyse the public health and economic impact of replacing TIV with QIV in different scenarios in Spain.

Methods

A dynamic transmission model was developed to estimate the number of influenza B cases prevented under TIV and QIV strategies (<65 years (high risk) and ≥65 years). This model considers cross-protective immunity induced by different lineages of influenza B. The output of the transmission model was used as input for a decision tree model that estimated the economic impact of switching TIV to QIV. The models were populated with Spanish data whenever possible. Deterministic univaria

SUBMITTER: Crepey P 

PROVIDER: S-EPMC7241783 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature