The value of CEP55 gene as a diagnostic biomarker and independent prognostic factor in LUAD and LUSC.

ABSTRACT:

Objective

To investigate the value of CEP55 as a diagnostic marker and independent prognostic factor in lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), and to analyze its co-expression genes and related signaling pathways.

Methods

TCGA database and GEO database were used to analyze the expression of CEP55 in LUAD and LUSC compared with normal tissues. The co-expression genes of CEP55 in LUAD and LUSC were excavated by cBioPortal and enriched by KEGG and GO. Establishing Receiver operating characteristic (ROC) curve to evaluate the value of CEP55 as a diagnostic and prognostic factor. The association between CEP55 expression and the clinicopathological features was evaluated using χ2 tests. ROC curves for diagnosis and prognosis detection were constructed. Prog

SUBMITTER: Fu L 

PROVIDER: S-EPMC7241791 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature