An open source tool to infer epidemiological and immunological dynamics from serological data: serosolver.

ABSTRACT: We present a flexible, open source R package designed to obtain biological and epidemiological insights from serological datasets. Characterising past exposures for multi-strain pathogens poses a specific statistical challenge: observed antibody responses measured in serological assays depend on multiple unobserved prior infections that produce cross-reactive antibody responses. We provide a general modelling framework to jointly infer infection histories and describe immune responses generated by these infections using antibody titres against current and historical strains. We do this by linking latent infection dynamics with a mechanistic model of antibody kinetics that generates expected antibody titres over time. Our aim is to provide a flexible package to identify infection histories

SUBMITTER: Hay JA 

PROVIDER: S-EPMC7241836 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature