Dynamic genetic architecture of yeast response to environmental perturbation shed light on origin of cryptic genetic variation.

ABSTRACT: Cryptic genetic variation could arise from, for example, Gene-by-Gene (G-by-G) or Gene-by-Environment (G-by-E) interactions. The underlying molecular mechanisms and how they influence allelic effects and the genetic variance of complex traits is largely unclear. Here, we empirically explored the role of environmentally influenced epistasis on the suppression and release of cryptic variation by reanalysing a dataset of 4,390 haploid yeast segregants phenotyped on 20 different media. The focus was on 130 epistatic loci, each contributing to segregant growth in at least one environment and that together explained most (69-100%) of the narrow sense heritability of growth in the individual environments. We revealed that the epistatic growth network reorganised upon environmental changes to alte

SUBMITTER: Zan Y 

PROVIDER: S-EPMC7241848 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature