Biomarkers of Delirium Duration and Delirium Severity in the ICU.

ABSTRACT:

Objectives

Both delirium duration and delirium severity are associated with adverse patient outcomes. Serum biomarkers associated with delirium duration and delirium severity in ICU patients have not been reliably identified. We conducted our study to identify peripheral biomarkers representing systemic inflammation, impaired neuroprotection, and astrocyte activation associated with delirium duration, delirium severity, and in-hospital mortality.

Design

Observational study.

Setting

Three Indianapolis hospitals.

Patients

Three-hundred twenty-one critically ill delirious patients.

Interventions

None.

Measurements and main results

We analyzed the associations between biomarkers collected at delirium onset and delirium-/coma-free days assessed through

SUBMITTER: Khan BA 

PROVIDER: S-EPMC7242000 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature