Utility of topical agents for radiation dermatitis and pain: a randomized clinical trial.

ABSTRACT:

Purpose

Although topical agents are often provided during radiation therapy, there is limited consensus and evidence for their use prophylactically to prevent or reduce radiation dermatitis.

Methods

This was a multi-site, randomized, placebo-controlled, blinded study of 191 breast cancer patients to compare the prophylactic effectiveness of three topical agents (Curcumin, HPR Plus™, and Placebo) for reducing radiation dermatitis and associated pain. Patients applied the topical agent to their skin in the radiation area site three times daily starting the first day of radiation therapy (RT) until 1 week after RT completion.

Results

Of the 191 randomized patients, 171 patients were included in the final analyses (87.5% white females, mean age = 58 (range = 36-88)). Mean

SUBMITTER: Ryan Wolf J 

PROVIDER: S-EPMC7242117 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature