Factors Disrupting Melatonin Secretion Rhythms During Critical Illness.

ABSTRACT:

Objectives

The circadian system modulates many important physiologic processes, synchronizing tissue-specific functions throughout the body. We sought to characterize acute alterations of circadian rhythms in critically ill patients and to evaluate associations between brain dysfunction, systemic multiple organ dysfunction, environmental stimuli that entrain the circadian rhythm (zeitgebers), rest-activity rhythms, and the central circadian rhythm-controlled melatonin secretion profile.

Design

Prospective study observing a cohort for 24-48 hours beginning within the first day of ICU admission.

Setting

Multiple specialized ICUs within an academic medical center.

Patients

Patients presenting from the community with acute onset of either intracerebral hemorrhage a

SUBMITTER: Maas MB 

PROVIDER: S-EPMC7242161 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature