Dynamics of a neuron-glia system: the occurrence of seizures and the influence of electroconvulsive stimuli : A mathematical and numerical study.

ABSTRACT: In this paper, we investigate the dynamics of a neuron-glia cell system and the underlying mechanism for the occurrence of seizures. For our mathematical and numerical investigation of the cell model we will use bifurcation analysis and some computational methods. It turns out that an increase of the potassium concentration in the reservoir is one trigger for seizures and is related to a torus bifurcation. In addition, we will study potassium dynamics of the model by considering a reduced version and we will show how both mechanisms are linked to each other. Moreover, the reduction of the potassium leak current will also induce seizures. Our study will show that an enhancement of the extracellular potassium concentration, which influences the Nernst potential of the potassium current, may

SUBMITTER: Erhardt AH 

PROVIDER: S-EPMC7242278 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature