TraPS-VarI: Identifying genetic variants altering phosphotyrosine based signalling motifs.

ABSTRACT: Patient stratification and individualized therapeutic strategies rely on the established knowledge of genotype-specific molecular and cellular alterations of biological and therapeutic significance. Whilst almost all approved drugs have been developed based on the Reference Sequence protein database (RefSeq), the latest genome sequencing studies establish the substantial prevalence of non-synonymous genetic mutations in the general population, including stop-insertion and frame shift mutations within the coding regions of membrane proteins. While the availability of individual genotypes are becoming increasingly common, the biological and clinical interpretations of mutations among individual genomes is largely lagging behind. Lately, transmembrane proteins of haematopoietic (myeloid and l

SUBMITTER: Ulaganathan VK 

PROVIDER: S-EPMC7242328 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature