Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.

ABSTRACT: Immunotherapy has emerged as a promising and effective treatment for cancer, yet the clinical benefit is still variable, in part due to insufficient accumulation of immune effector cells in the tumour microenvironment. Better understanding of tumour-infiltrating lymphocytes (TILs) from nonhuman primate tumours could provide insights into improving effector cell accumulation in tumour tissues during immunotherapy. Here, we characterize TILs in a cynomolgus macaque tumour model in which the tumours were infiltrated with CD4⁺ and CD8⁺ T cells and were eventually rejected. The majority of CD4⁺ and CD8⁺ TILs exhibited a CD45RA^-CCR7^- effector memory phenotype, but unlike circulating T cells, they expressed CD69, a marker for tissu

SUBMITTER: Satooka H 

PROVIDER: S-EPMC7242367 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature