Extracellular vesicles produced by human and animal Staphylococcus aureus strains share a highly conserved core proteome.

ABSTRACT: Staphylococcus aureus is an important opportunistic pathogen of humans and animals. It produces extracellular vesicles (EVs) that are involved in cellular communication and enable inter-kingdom crosstalk, the delivery of virulence factors and modulation of the host immune response. The protein content of EVs determines their biological functions. Clarifying which proteins are selected, and how, is of crucial value to understanding the role of EVs in pathogenesis and the development of molecular delivery systems. Here, we postulated that S. aureus EVs share a common proteome containing components involved in cargo sorting. The EV proteomes of five S. aureus strains originating from human, bovine, and ovine hosts were characterised. The clustering of EV proteomes reflected the diversity of t

SUBMITTER: Tartaglia NR 

PROVIDER: S-EPMC7242376 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature