Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection.

ABSTRACT: Infection with influenza can be aggravated by bacterial co-infections, which often results in disease exacerbation. The effects of influenza infection on the upper respiratory tract (URT) microbiome are largely unknown. Here, we report a longitudinal study to assess the temporal dynamics of the URT microbiomes of uninfected and influenza virus-infected humans and ferrets. Uninfected human patients and ferret URT microbiomes have stable healthy ecostate communities both within and between individuals. In contrast, infected patients and ferrets exhibit large changes in bacterial community composition over time and between individuals. The unhealthy ecostates of infected individuals progress towards the healthy ecostate, coinciding with viral clearance and recovery. Pseudomonadales associate

SUBMITTER: Kaul D 

PROVIDER: S-EPMC7242466 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature