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Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy.

ABSTRACT: BACKGROUND:There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-? (A?) cerebral amyloid angiopathy (CAA). OBJECTIVE:To determine the profile of biomarkers relevant to neurodegenerative disease in the CSF of patients with CAA. METHODS:We performed a detailed comparison of CSF markers, comparing patients with CAA, Alzheimer's disease (AD), and control (CS) participants, recruited from the Biomarkers and Outcomes in CAA (BOCAA) study, and a Specialist Cognitive Disorders Service. RESULTS:We included 10 CAA, 20 AD, and 10 CS participants (mean age 68.6, 62.5, and 62.2 years, respectively). In unadjusted analyses, CAA patients had a distinctive CSF biomarker profile, with significantly lower (p?

SUBMITTER: Banerjee G 

PROVIDER: S-EPMC7242825 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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<h4>Background</h4>There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-β (Aβ) cerebral amyloid angiopathy (CAA).<h4>Objective</h4>To determine the profile of biomarkers relevant to neurodegenerative disease in the CSF of patients with CAA.<h4>Methods</h4>We performed a detailed comparison of CSF markers, comparing patients with CAA, Alzheimer's disease (AD), and control (CS) participants, recruited from the Biomarkers and Outcomes in CAA (BOCAA) study, and a Special  ...[more]

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