Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy.

ABSTRACT:

Background

There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-β (Aβ) cerebral amyloid angiopathy (CAA).

Objective

To determine the profile of biomarkers relevant to neurodegenerative disease in the CSF of patients with CAA.

Methods

We performed a detailed comparison of CSF markers, comparing patients with CAA, Alzheimer's disease (AD), and control (CS) participants, recruited from the Biomarkers and Outcomes in CAA (BOCAA) study, and a Specialist Cognitive Disorders Service.

Results

We included 10 CAA, 20 AD, and 10 CS participants (mean age 68.6, 62.5, and 62.2 years, respectively). In unadjusted analyses, CAA patients had a distinctive CSF biomarker profile, with significantly lower (p < 0.01) median concentrations of Aβ38, Aβ40

SUBMITTER: Banerjee G 

PROVIDER: S-EPMC7242825 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature