Exercise Promotes Neurite Extensions from Grafted Dopaminergic Neurons in the Direction of the Dorsolateral Striatum in Parkinson's Disease Model Rats.

ABSTRACT:

Background

Cell transplantation is expected to be a promising treatment for Parkinson's disease (PD), in which re-innervation of the host striatum by grafted dopamine (DA) neurons is essential. In particular, the dorsolateral part of the striatum is important because it is the target of midbrain A9 DA neurons, which are degenerated in PD pathology. The effect of exercise on the survival and maturation of grafted neurons has been reported in several neurological disease models, but never in PD models.

Objective

We investigated how exercise influences cell transplantation for PD, especially from the viewpoint of cell survival and neurite extensions.

Methods

Ventral mesencephalic neurons from embryonic (E12.5) rats were transplanted into the striatum of adult 6-OHDA-lesi

SUBMITTER: Torikoshi S 

PROVIDER: S-EPMC7242856 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature