Participation of Women and Older Participants in Randomized Clinical Trials of Lipid-Lowering Therapies: A Systematic Review.

ABSTRACT: Importance:Randomized clinical trials (RCTs) of lipid-lowering therapies form the evidence base for national and international guidelines. However, concerns exist that women and older patients are underrepresented in RCTs. Objective:To determine the trends of representation of women and older patients (≥65 years) in RCTs of lipid-lowering therapies from 1990 to 2018. Data Sources:The electronic databases of MEDLINE and ClinicalTrials.gov were searched from January 1990 through December 2018. Study Selection:RCTs of lipid-lowering therapies with sample sizes of at least 1000 patients and follow-up periods of at least 1 year were included. Data Extraction and Synthesis:Two independent investigators abstracted the data on a standard data collection form. Main Outcomes and Measures:Patterns of

SUBMITTER: Khan SU 

PROVIDER: S-EPMC7243092 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature