Electroanalysis Applied to Compatibility and Stability Assays of Drugs: Carvedilol Study Case.

ABSTRACT: Carvedilol (CRV) is a non-selective blocker of α and β adrenergic receptors, which has been extensively used for the treatment of hypertension and congestive heart failure. Owing to its poor biopharmaceutical properties, CRV has been incorporated into different types of drug delivery systems and this necessitates the importance of investigating their compatibility and stability. In this sense, we have investigated the applicability of several electroanalytical tools to assess CRV compatibility with lipid excipients. Voltammetric and electrochemical impedance spectroscopy techniques were used to evaluate the redox behavior of CRV and lipid excipients. Results showed that Plurol® isostearic, liquid excipient, and stearic acid presented the greatest anode peak potential variation, and these w

SUBMITTER: de Carvalho MF 

PROVIDER: S-EPMC7243106 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature