Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites.

ABSTRACT:

Aims

Atherosclerosis develops near branches and bends of arteries that are exposed to disturbed blood flow which exerts low wall shear stress (WSS). These mechanical conditions alter endothelial cells (EC) by priming them for inflammation and by inducing turnover. Homeobox (Hox) genes are developmental genes involved in the patterning of embryos along their anterior-posterior and proximal-distal axes. Here we identified Hox genes that are regulated by WSS and investigated their functions in adult arteries.

Methods and results

EC were isolated from inner (low WSS) and outer (high WSS) regions of the porcine aorta and the expression of Hox genes was analysed by quantitative real-time PCR. Several Hox genes (HoxA10, HoxB4, HoxB7, HoxB9, HoxD8, HoxD9) were significantly enriched

SUBMITTER: Souilhol C 

PROVIDER: S-EPMC7243277 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature