Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish.

ABSTRACT:

Aims

A robust inflammatory response to tissue injury is a necessary part of the repair process but the deposition of scar tissue is a direct downstream consequence of this response in many tissues including the heart. Adult zebrafish not only possess the capacity to regenerate lost cardiomyocytes but also to remodel and resolve an extracellular scar within tissues such as the heart, but this scar resolution process remains poorly understood. This study aims to characterize the scarring and inflammatory responses to cardiac damage in adult zebrafish in full and investigate the role of different inflammatory subsets specifically in scarring and scar removal.

Methods and results

Using stable transgenic lines, whole organ imaging and genetic and pharmacological interventions, we

SUBMITTER: Bevan L 

PROVIDER: S-EPMC7243279 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature