Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans.

ABSTRACT:

Background

The cline of human genetic diversity observable across Europe is recapitulated at a micro-geographic scale by variation within the Italian population. Besides resulting from extensive gene flow, this might be ascribable also to local adaptations to diverse ecological contexts evolved by people who anciently spread along the Italian Peninsula. Dissecting the evolutionary history of the ancestors of present-day Italians may thus improve the understanding of demographic and biological processes that contributed to shape the gene pool of European populations. However, previous SNP array-based studies failed to investigate the full spectrum of Italian variation, generally neglecting low-frequency genetic variants and examining a limited set of small effect size alleles, which

SUBMITTER: Sazzini M 

PROVIDER: S-EPMC7243322 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature